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Within the vast expanse of the large intestine microbiome, there exists the capacity to convert carnitine and choline into trimethylamine (TMA), which is subsequently metabolised by the hepatic enzyme flavin mono-oxygenase (FMO) family, such as FMO-1 and FMO-3, ultimately culminating in the formation of TMAO (Reference Thomas and Fernandez8,Reference Gatarek and Kaluzna-Czaplinska10)

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